ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82
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چکیده
منابع مشابه
Roles of Renin-Angiotensin System in the Regulation of Prostate Cancer Bone Metastasis: A Critical Review
Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...
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Therapies that target cancer cells may have unexpected effects on the tumor microenvironment that affects therapy outcomes or render therapy resistance. Prostate cancer (PCa) bone metastasis is uniquely associated with osteoblastic bone lesions and treatment with cabozantinib, a VEGFR-2 and MET inhibitor, leads to a reduction in number and/or intensity of lesions on bone scans. However, resista...
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The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 ve) and DU145 (CD44 ve) and four breast cancer cell lines was confirmed by immunoblotting and immunocytochemistry. In cell adhesion assays, PC3 but...
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chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
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چکیده : قرآن چشمه سار زلال هدایتی است که از سوی خداوند حکیم نازل شده تا بشر را به سر منزل کمال برساند. و در این راستا از شیوه های گوناگون بیانی خطابی و بلاغی استفاده کرده تا با فطرت زیبا طلب انسان درآمیزد و اورا مقهور خویش ساخته، به سوی کمالات سوق دهد.ازجمله جنبه های بارز اعجاز بیانی قرآن وجود فواصل در پایان آیات است که کار برد سجع و قافیه در کلام بشر شبیه آن است. برخی ازعلمای سلف تفاوت هایی ب...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2017
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2017.42